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Home» News»Prostate cancer: radium-223 does not affect efficacy or safety of subsequent chemotherapy

Prostate cancer: radium-223 does not affect efficacy or safety of subsequent chemotherapy

Saheli 28 Mar 2016 News Comments Off on Prostate cancer: radium-223 does not affect efficacy or safety of subsequent chemotherapy 2 Views

Takeaway

  • Overall survival was similar in patients receiving chemotherapy following radium-223 and placebo, irrespective of prior docetaxel use.
  • Chemotherapy was well-tolerated in patients who had previously received radium-223.

Key results

  • 142 radium-223 and 64 placebo patients received subsequent chemotherapy, most commonly docetaxel (70% radium-223 vs 72% placebo) and mitoxantrone (16% radium-223 vs 20% placebo).
  • 61% and 58% of patients, respectively, had received prior docetaxel.
  • Radium-223 patients started subsequent chemotherapy later than placebo patients.
  • Chemotherapy duration was similar between groups.
  • Median hematologic values remained nearly constant up to 18 mo following start of chemotherapy, regardless of prior docetaxel treatment.
  • <10% of patients in both groups had grades 3-4 hematologic values.
  • Median overall survival rates from start of chemotherapy were 16.0 and 15.8 mo following radium-223 and placebo, respectively.

[Source:- Univadis]

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Posted by : Saheli
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